Zoloft has been around since 1991 and currently holds an advantage over Lexapro, which was introduced roughly a decade later, regarding which is prescribed more to patients battling depression and anxiety. With that said, because each offers the same types of efficacy, as well as roughly the same types of side effects (sleepiness, insomnia, nausea, muscle ache and sexual dysfunction), the final decision on which one works best for a particular person may come down to a bit of trial and error. Different bodies react differently to medications, which means that while some people may react better to lexapro, other’s may find that zoloft is the better option.